HLC High Potency - 60 CP

Temperature Stable Probiotics

HLC High Potency 60 CAP by Pharmax.

HLC – Highest survival through the stomach

The pH of the empty stomach is between 1.5 and 1.9 whereas, due to the buffering capacity of food, the pH is raised to between 3.8 and 4.3 in the full stomach. The aggressive nature of the stomach acts as an excellent barrier to invasion by potentially pathogenic microbes. So, for probiotics to be effective, they must survive in high numbers under the same environmental stresses as would severely inhibit or eradicate other bacteria. The HLC organisms were compared with other probiotic strains for their ability to survive passage.

With over 90% survival in the full stomach and over 50% survival in the harshest environment of the empty stomach, the HLC organisms proved particularly robust and well adapted to the human stomach. This was in contrast to other probiotic organisms, which showed great sensitivity to gastric conditions and poor adaptation to the human host.

This study also demonstrated that probiotics should be taken in association with a meal to ensure maximum survival.

HLC - Proven attachment to human epithelial cells and antagonism to Candida albicans..

In the small intestine (duodenum, jejunum, ileum) the transit time is rapid relative to the "doubling time" of normal flora bacteria so, if they are unable to attach or otherwise become associated with the epithelial surface, they will be washed through. Lactobacilli, particularly Lactobacillus acidophilus are the most important colonizing organism of the small intestine and it is therefore critical that any Lactobacillus strains used as probiotics are capable of human epithelial cell attachment.

HLC - Proven in clinical trials

Probiotics from the HLC range are continuously tested and shown to be effective in independent, placebo controlled, clinical trials. All such studies get published in peer-reviewed scientific journals. Results from recent clinical studies are outlined below.

Trial 1: Undertaken at Addenbrookes Hospital, Cambridge, U.K.

Aim: Reduction in post-antibiotic re-growth of potentially pathogenic facultative microorganisms,

Results: HLC Intensive significantly prevented post antibiotic increase in Staphylococci, Enterobacteriaceae and Enterococci. These microorganisms are associated with post-antibiotic infection and overgrowth as well as the acquisition and transfer of antibiotic resistance.

Trial 2: Undertaken at Addenbrookes Hospital, Cambridge, U.K.

Aim: Prevention of post-antibiotic overgrowth of Clostridium difficile in hospitalized patients Results: HLC Intensive lowered frequency of Clostridium difficile infection and overgrowth to the extent that justified its use in all hospitalized patients undertaking antibiotic therapy.

With further clinical trials already in progress, it is clear that the HLC range of probiotics from Pharmax is leading the way in innovative, clinical probiotic research and will pave the way for recognition of the benefits of probiotics in many new aspects of human health and disease.

The Functions of Lactobacilli & Bifidobacteria in the G.I. tract.
Their major beneficial physiological functions are as follows.
Well established.
Protect against enteric infection, overgrowth and dysbiosisStimulate the development and balancing of the neonatal immune system.
Continuously stimulate the mucosal immune barrier throughout life.
Stimulate the digestion and absorption of nutrients such as lactose (by producing lactase) and minerals (by action of lactic acid).
Stimulate intestinal motility.
Less well established:Less well established:
Decrease absorption of dietary cholesterol by binding and excretion.
Decrease production of intestinal mutagens and carcinogens

However, for most people, the benefits of having high numbers of Lactobacilli and Bifidobacteria are not fully achieved. This is because these organisms are the most adversely affected by any disturbance of the G.I. tract, leading to dramatically reduced populations and resultant dysbiosis. This can be overcome by supplementing with products from the Pharmax HLC range – the benchmark of probiotics and probiotic therapy.

HLC – Summary
Human strains.
Proven by human double blind placebo controlled clinical trial.
Tailored to address specific health/disease presentations.
Dysbiosis and overgrowth.
Chronic inflammatory conditions.
Gastrointestinal (GI) tract syndromes e.g. Irritable bowel syndrome (IBS)
Stressful lifestyle
Immune maintenance with age
High potency.
Guaranteed quality by independent potency analysis with each delivery.
Unique and proven synergistic interactions with other nutritionals.
HLC High Potency (4 billion Lactobacillus acidophilus and Bifidobacterium bifidum per capsule)

To replace the normal bowel flora, we always recommend Pharmax’s human lactic commensals, i.e. HLC High Potency for bowel restoration.

Dosage: 1 - 2 capsules after each meal.

Cold packs not required during shipping but weather reports are checked daily for unusual unforeseen circumstances at weather.com.