Side Effects of Cipro

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A new research article explains how quinolone antibiotics (including "Cipro") cause joint and tendon ruptures... See also one young man's testimony on the potential for side effects. Reprint of Dr. Shoskes newsgroup comment on antibiotics in prostatitis treatment.

Cipro (Ciprofloxin) is a member of the quinolone group of antibiotics. Peak blood levels are reached 1-2 hours after dosing. If you take an ANTACID containing magnesium or aluminum hydroxide (most have one or both), it will bind up to 90% of the drug, rendering it mostly ineffective. Same is true with zinc, iron, and calcium. It reaches optimum blood levels if taken 2 hours after a meal. If you take THEOPHYLLINE) for asthma, Cipro slows down the breakdown of Theophylline, and it will cause severe nervousness as you would expect with an overdose (could be fatal!). Cipro does the same with CAFFEINE, and will build up higher blood levels of caffeine, causing nervousness and CNS stimulation.

Cipro is effective against gram positive and gram negative bacteria. It works by interfering with an enzyme that bacteria need to replicate their DNA. Cipro enters tissue, including the prostate, and can be isolated from prostatic secretions.

RECOMMENDED DOSE FOR PROSTATITIS: 500mg every 12 hours for 28 days.

*EFFECTIVE AGAINST:

AEROBIC GRAM POSITIVE:

AEROBIC GRAM NEGATIVE:

Effective against 90% of the strains of the following -- In Vitro (test-tube) - - - -

AEROBIC GRAM POS:

AEROBIC GRAM NEG:

OTHER:

RESISTANT BACTERIA NOT HELPED BY CIPRO: Most strains of: Burkholderia cepacia, Stenotrophomonas maltophilia, Bacteroides fragilis, Clostridium difficile- Cipro is slightly less effective in an acid PH.- Resistance develops slowly to Cipro (multi-step mutations)- Synergistic (stronger) effects occur with Cipro if given with Flagyl (metronidazole), Cleocin (Clindamycin), or aminoglucocide or beta-lactam class antibiotics.

CONTRAINDICATIONS: Should not be used by persons with a history of hypersensitivity to Cipro, or other quinolones. Not to be used by persons under the age of 18.

WARNINGS: All quinolones cause erosion of cartilage in weight-bearing joints. They may cause convulsions, increases intracranial pressure, toxic psychosis, CNS stimulation (i.e.nervousness, light-headedness, confusion, hallucinations). Should not be used in anyone with seizure disorders, or cerebral arteriosclerosis. There have been deaths due to anaphylactic shock, and cardiovascular collapse. Also occurring are tingling, itching, facial swelling, and difficult breathing.

DISCONTINUE at the first sign of a rash or any hypersensitivity. Pseudomembranous colitis has been reported from nearly all antibacterial agents (mild to life-threatening), and anyone taking Cipro having diarrhea should immediately check with his prescribing physician. Antibacterial drugs may kill off normal intestinal flora, resulting in an overgrowth of Clostridia. It produces a toxin that is a primary cause of "antibiotic-associated- colitis". Achilles and other tendon ruptures requiring surgical repair, resulting in prolonged disability can occur from quinolone use. Discontinue Cipro, and consult your physician, if you experience pain, inflammation, or tendon rupture.

Crystaluria (particles out of solution in urine) may occur, particularly if the urine is alkaline. While taking Cipro, maintain hydration (8-8oz glasses of water daily min.) and drink Orange or Cranberry juice, or apple cider vinegar (2 tsp. with 1 tsp. honey in 8 oz. water) to maintain acidity of the urine. Photosensitivity (sunburn) occurs easily. Stay out of the sun all you can, or wear sunscreen (spf 30) if you can't. Monitor liver, kidney functions, and blood chemistry during prolonged therapy.

DRUG INTERACTIONS:

ADVERSE REACTIONS:

The following were reported as less than one percent:

These are only the clinical side effects, sub clinical side effects are unknown.

No antibiotic should be taken unless you have been diagnosed with a bacterial infection. Antibiotics are not preventative medicine.

If you choose to take Antibiotics, we recommend you take a full spectrum probiotic and liver support to protect yourself from unwanted side effects.