Folinic Acid/Trimethylglcyine - Transdermal Cream - 2 OZ Tube

Folinic Acid/Trimethylglcyine - Transdermal Cream by Health Pro Labs

Transdermal Folinic Acid and Trimethylglycine Transdermal Cream is an interesting combination of two substances that have two completely different functions; however, the combination is formidable because of the co-dependency of their biochemistries. Let's take a closer look at this particular aspect as well as some of the outstanding and effective properties of these two substances.

Most of us are familiar with the well known folate vitamin B-9 called folic acid, and less familiar with its metabolically active form called folinic acid (5-formyl tetrahydrofolate) or sometimes referred to as leucovorin. Folinic acid is a natural form of the folates found in foods, while folic acid is actually a synthetic form of the folates. Folinic acid is much more stable than folic acid and therefore remains longer in the body. Folinic acid also aids in the synthesis of the body's genetic material and chromosomes, the DNA and the RNA, proteins, and in the appropriate functioning of iron in the body. Another very important benefit of folinic acid is its ability to cross the blood brain barrier making it transportable into the brain, affecting neurological functioning. This particular benefit has enabled folinic acid to be more easily assimilated into the central nervous system as well, much more effectively than folic acid.

Overall, folate deficiency is believed to be the most common vitamin deficiency in the world today. Although generally overlooked, the rise in processed foods, fewer home cooked meals, poorer food selection, increased gastrointestinal disorders, and malabsorption issues can all be attributed to widespread folate deficiency.

Trimethylgylcine, (TMG) also known as Glycine Betaine, is much more common in the scientific biochemical world because of its methylation properties. Methylation is a necessary biochemical reaction in the body. What defines this methylation process of TMG is the fact that it is derived from plant sources and has three methyl groups attached to each molecule of glycine. This function identifies TMG as a methyl donor: a substance that can transfer a methyl group (which consists of a carbon atom attached to three hydrogen atoms) to another substance. This natural process is called methylation can make new cells; create natural antioxidants, and break down harmful chemicals. Methylation is not only a vital biochemical reaction in the body, but it supports many metabolic systems in the body such as: cardiovascular, immune, hormonal, detoxification, RNA/DNA, just to name a few.

Many important biochemical processes rely on methylation. In the body a natural conversion takes place whereby methionine is converted into homocysteine and homocysteine. TMG is known for its primary biochemical process of converting the dangerous amino acid homocysteine into the beneficial amino acid methionine. These conversions support the immune, cardiovascular, detoxification and hormonal systems in the body.

Methionine is found primarily in animal protein and is important for the function of the heart and blood vessels, muscle tissue, immune and nervous systems. Folic acid is required for proper metabolism of methionine, but in the conversion of methionine to homocysteine, the methylation process requires SAMe - s-adenoslymethione. SAMe is the body's universal methyl donor that can improve mood, energy, well-being, alertness, concentration and visual clarity. TMG and folate are the precursors to SAMe and can increase the body's levels of SAMe in order to facilitate this methylation process. Researchers now believe that major depressive disorders, cardiovascular diseases and neuropsychiatry can be linked to a folate deficiency. Both TMG and folate are crucial to the production of SAMe that plays a role in determining mood by affecting the catecholamine neurotransmitters which are the hormonal neurotransmitters.

On the other hand, in the conversion of homocysteine to methionine, this methylation process requires B-12 methylcobalamin, TMG and the "principal circulating folate", which is the tetrahydrofolate form, known as folinic acid. If the body does not have enough folate to convert homocysteine into methionine, then high blood levels of homocysteine occur. Low folate invariably accompanies high homocysteine.

High levels of homocysteine in the blood is widely recognized as being toxic to the endothelial cells that make up our entire circulatory system including the heart, capillaries and blood vessels. It activates inflammatory processes in the endothelial cells that lead to oxidation of molecules in the cells. This leads to the generalized inflammatory process that causes "hardening of the arteries". Therefore, increased homocysteine levels in the blood can possibly lead to many degenerative diseases such atherosclerosis, coronary heart disease, stroke, Alzheimer's, osteoporosis, arthritis, cancer, and depression.

Another interesting fact about homocysteine is that it has the capacity to impact all methylation and sulphur group transference processes in the body. Trans-sulphuration is a process that breaks down homocysteine into two amino acids called taurine and cysteine. Taurine is known for cardiac support and liver support, detoxification, bile acid formation and cholesterol excretion. Cysteine directly impacts the production of glutathione, a potent antioxidant that has protective effects against DNA/RNA damage, as well as being involved in heavy metal and chemical detoxification and immune function. Many children on the autistic spectrum have difficulty producing taurine and cysteine in addition to having a faulty methylation system. High homocysteine in these cases will have an overall impact on the child's cognitive functioning, focus, concentration and the processing of language.

Folinic acid and trimethylglycine help protect against the debilitating effects of high levels of homocysteine in the blood. The transdermal combination of folinic acid and trimethylglycine can be very effectively absorbed into the body, especially in cases of gastrointestinal malabsorption and folate deficiency. One-quarter teaspoon of Transdermal Folinic Acid and Trimethylglycine can be placed on the thin skin of the body twice daily or as directed by your healthcare professional.

Ingredients Deionized Water, Medium Chain Triglycerides, Trimethylglycine, Shea Butter, Cetyl Alcohol, Stearic Acid, Lecithin, Sodium Hydroxymethyl-glycinate, Potassium Sorbate, Xanthan Gum, Folinic Acid.